ATLAS-HUMAN
Human genetics and curated evidence help establish relevance to disease. This layer informs which biological mechanisms warrant testing in adipose tissue and skeletal muscle.
CANARY ATLAS / EVIDENCE
Human evidence meets cellular biology.
ATLAS-HUMAN and ATLAS-CELL form a shared evidence stack for adipose tissue and skeletal muscle.
ATLAS-HUMAN + ATLAS-CELL
Biology, hardware, and compute.
A shared evidence stack for adipose tissue and skeletal muscle.
- OpenAI reasoning
- Integrate evidence and delivery criteria.
- Causal evidence
- Genetics and perturbations guide testing.
- Representation
- Model adipocyte and muscle states.
- Evidence preparation
- Curate, harmonize, and annotate.
- Data
- Human genetics, cell assays, images, and sequences.
Human relevance and cellular response inform each nomination.
ATLAS-HUMAN + ATLAS-CELL
Human relevance. Cellular response.
ATLAS-CELL
Perturbation and phenotyping examine what changes when target activity is altered. Cellular response is considered alongside human evidence before a target is nominated.
THE EVIDENCE STACK
From biological data to a testable hypothesis.
- 01
Data
Human genetics, cell assays, images, and sequences provide complementary views of biology.
- 02
Evidence preparation
Curate, harmonize, and annotate the inputs so their biological context can inform interpretation.
- 03
Representation
Model adipocyte and muscle states to connect measurements with the tissue biology under study.
- 04
Causal evidence
Genetics and perturbations support causal hypotheses for testing. Associations alone do not establish that changing a target will produce a therapeutic effect.
- 05
Reasoning and nomination
Integrate the evidence with delivery criteria, then identify a next experiment for scientist review.
DECISION CRITERIA
A nomination needs more than a signal.
Human signal
Does the available human evidence support the disease mechanism being investigated?
Cell response
Does changing target activity produce a relevant, measurable cellular response?
Delivery fit
Can the intended cargo and tissue be addressed within the HYPER-15™ delivery design?
Atlas is designed to bring these questions together. New experimental measurements update the evidence and guide whether to advance, hold, or reject a hypothesis.
Explore the experimental cycle