Canary’s First-in-class Dual RNAi Gene Silencing Offers a Novel Approach to Weight Loss and Metabolic Disease Management

CCT-217 Demonstrates Significant Weight Loss and Preserves Lean Body Mass with Potential for Single or Twice-Yearly Dosing
New York, November 18thth, 2024 – Canary Cure, a biotechnology company focused on developing innovative RNAi therapies, today announced the results of a diet-induced-obesity (DIO) mouse study demonstrating the potential of its first-in-class dual siRNA therapy, CCT-217, to achieve significant weight loss and improve metabolic health.
Key Findings from the Study:
Canary Cure’s founder and CEO, Raj Reddy is presenting the data for the first time at the 4th Metabolic Diseases; Breakthrough Discoveries in Diabetes & Obesity at Monash University in Australia.
“We are extremely excited about the potential of CCT-217 to transform the treatment of obesity,” said Raj Reddy, founder and CEO of Canary Cure. “Our pre-clinical data clearly demonstrate the drug’s ability to induce significant and sustained weight loss while preserving lean body mass and improving metabolic health. With the potential for infrequent dosing and a strong pipeline of RNAi therapies in development, Canary Cure is well-positioned to address the growing global obesity epidemic and make a positive impact on millions of lives.”
Canary Cure’s CCT-217 therapy targets the CB1r gene, which is part of the endocannabinoid system (ECS). The ECS influences energy balance, fat storage, and food intake. By targeting CB1r gene with siRNA, CCT-217 aims to promote weight loss and improve metabolic health. Importantly, CCT-217 is designed to be peripherally restricted, meaning it does not penetrate the brain. This brain penetration restriction enhances safety by avoiding potential side effects associated with CB1r gene modulation in the central nervous system (CNS).
Professor Lawrence Kazak of McGill University and Canada Research Chair in Adipocyte Biology, a renowned expert in the field of obesity and metabolic health and a member of Canary Cure’s Scientific Advisory Board, commented, “Obesity is a complex disease with considerable health implications. There is a significant unmet need for safe and effective treatments that treats the root causes of the disease. Novel therapies like CCT-217 which focus on harnessing the body’s natural fat-burning capacity offer a promising new approach to not just managing weight, but truly modifying the course of obesity and its associated metabolic complications.”
Obesity is a major risk factor for numerous chronic diseases, including type 2 diabetes, heart disease, and stroke. Over 40% of adults worldwide are overweight or obese. The global obesity market is projected to reach above $150 billion by 2030.
About Canary Cure
Canary Cure is a privately held biotechnology company dedicated to developing innovative RNA interference (RNAi) therapies for the treatment of metabolic diseases. The company’s lead candidate, CCT-217, is a first-in-class dual siRNA therapy targeting CB1r and zfp423 for the treatment of obesity. Canary Cure is committed to advancing RNAi technology to deliver transformative therapies that improve the lives of patients.

www.canarycure.com

Contact: Anna Wang – Chief Strategy Officer anna@canarycure.com

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